The event, which raises money for the Crossroads rehabilitation clinic, will take place on July 28 in Chicago.
In addition to Clapton, the festival will feature performances by B.B. King, Jeff Beck, John Mayer, Sheryl Crow, Willie Nelson, Vince Gill, Buddy Guy, Robert Randolph and the Family Band, Steve Winwood, Albert Lee, Derek Trucks, Alison Krauss & Union Station, John McLaughlin, Sonny Landreth, the Robert Cray Band, Hubert Sumlin, Doyle Bramhall and Jimmie Vaughan.