The show, which will be in front of the biggest audience that Genesis has ever had, will take place in an ancient Rome hippodrome.
The performance will mark the final show of the band’s tour, and will take place on July 14.
Genesis is touring this summer for the first time in 15 years. Tony Banks, Phil Collins and Mike Rutherford will first take the stage together in Helsinki on June 11. Former member Peter Gabriel is not joining the tour.