With chances to win in four categories, the band is expected to steal the show at the ceremony which will take place on November 2 in Copenhagen.
The Chili Peppers are competing for the title in the Best Rock Group, Best Disc, and Best Song (Dani California) categories.
Several other artists received three nominations, including Madonna, Shakira, Nelly Furtado, Christina Aguilera, Kanye West and Muse.
The evening will be hosted by Justin Timberlake. The singer will also perform during the ceremony.