De Niro will film some scenes for "The Good Shepherd" in the presidential palace, which he toured with President Leonel Fernandez, a spokesman for the national film office said.
Further details about the meeting Friday were not released.
Several of the country’s historic districts will be used for scenes that are supposed to take place in Africa. Production was expected to remain in the Dominican Republic one week.
"The Good Shepherd," directed by De Niro, recounts the history of the CIA. Matt Damon plays James Wilson, one of the spy agency’s founders; Angelina Jolie plays his wife.
Damon has arrived in the country, and Jolie was expected to arrive over the weekend.