La chanteuse canadienne Shania Twain profite de cette association pour lancer sa nouvelle chanson Shoes. Le clip qui accompagne le single mettra en vedette les comédiennes du célèbre feuilleton, Teri Hatcher, Eva Longoria, Felicity Huffman et Marcia Cross.
Le disque permettra aussi de redécouvrir plusieurs chanteuses qui reprendront des chansons de différents artistes.
Voici la liste complète des chansons du disque Music From and Inspired by Desperate Housewives :
"Dialog / Mary Alice"
"God Bless the American Housewife," SheDaisy
"Dialog / Edie"
"Shoes," Shania Twain
"Band of Gold," Anna Nalick
"Dialog / Lynette"
"Mother’s Little Helper," Liz Phair
"Mrs. Robinson," Indigo Girls
"Harper Valley P.T.A.," Martina McBride
"Dialog / Bree"
"Running Out of Time," Leann Rimes
"Treat Me Right (I’m Yours for Life)," Joss Stone
"One’s on the Way," Sara Evans
"Dialog / Gabrielle"
"Boom Boom," Macy Gray
"Young Hearts Run Free," Gloria Estefan
"Dialog / Susan"
"Damsel in Distress," Idina Menzel
"Dreams of the Everyday Housewife," k.d. lang
"Dialog / Mary Alice"
"Theme," Danny Elfman