Entertainment Weekly has learned that the couple is currently in negotiations to resume their respective roles in the new Scream trilogy.
Screenwriter Kevin Williamson is now working on the new scripts. He approached the couple to return to their former roles as journalist Gale Weathers and deputy sheriff, Dwight "Dewey" Riley.
However, it is unknown whether Neve Campbell’s character will be returning to the film.
Scream 4 is set to shoot this autumn and open next year.
The first three films earned over 300 million dollars at the American box office.
Meanwhile, Cox stars in the television series Cougar Town. She is also set to play in the film The Big Chance, which is still in the process of being written.