The star, accompanied by actor Don Cheadle, and two former Olympic athletes, are in Egypt, after spending several hours in China campaigning for assistance in Darfour.
Clooney has been bringing world-wide attention to Darfour, a war-torn region of Sudan, where millions of refugees are being found dead.
The actor has chosen China and Egypt to ask for help because their politicians have been successful working with the leaders of Sudan in the past. Earlier this year, Clooney went before the United Nations to ask for help in the region.
Clooney is expected to return to the United States on Thursday.