Nicola Formichetti is leaving Mugler.
The designer is to depart the French fashion house after spending just over two years as creative director, and he has been thanked by the company for creating a "new audience" for their clothes.
Joel Palix, president of Clarins Fragrance Group and director general of Mugler, said in a statement: "Nicola has accomplished our original mission of bringing his energy to the brand.
"With his talent for communication and understanding of modern imagery and design, Nicola has been instrumental in attracting a new audience which is undeniably crucial for the future strategy of the house.
"He will be a historical part of the Mugler legacy and known as the force that catapulted us forward."
Nicola unveiled his first collection for the label for autumn/winter 2011-12, and the show featured a catwalk appearance from his close friend Lady Gaga.
Despite the "mutual agreement" to step down at Mugler, Nicola will still be keeping busy as he works as the creative director of Uniqlo, creates fashion for his own line Nicopanda and acts as Gaga’s stylist.
Mugler is expected to release a "new strategic plan" soon, which plans to "build on its highly successful legacy in fragrance and its new momentum in fashion."