The actress, who earned an actress for her work in the film The Constant Gardener, will not return to her role as Evelyn Carnahan O’Connell in the science-fiction film.
Weisz, who played the wife of the film’s lead character, played by Brendan Fraser, is reportedly too busy to take park in the movie.
Filming of the third installment of The Mummy film franchise will begin in July. The project’s budget is set at $100 million US. Rob Cohen, who directed the film The Fast and The Furious, will be behind the camera.