Stone will be replaced by Renée Zellweger in the film, according to Variety.
Written and being directed by Olivier Dahan (La vie en rose), My Very Own Love Song is the story of a wheelchair-bound former singer and a firefighter, who is hospitalised following an on-the-job accident.
Forest Whitaker (The Last King of Scotland) and Madelin Zima (A Cinderella Story) have also joined the cast. Filming is set to begin next month in Kansas and New Orleans.
In the meantime, we can next see Renée Zellweger with Viggo Mortensen, Jeremy Irons and Ed Harris in the western flick Appaloosa. The film, directed by Harris, opens in theatres on October 3.