The legendary musician will be calling Las Vegas home for the next few years, performing at the 4 000-seat Hard Rock Hotel & Casino venue.
Santana, whose 38-show concert tour in 2008 earned nearly $16 million, will play the biggest hits from his career that spans nearly 40 years.
The company Frank the Plumber, who recently designed the set for Madonna, will have the honours of preparing the Hard Rock stage for the 62-year-old Mexican guitar player and singer.