The two stars will play pharmaceutical rivals in the quest for lucrative innovations in the suspense, that will also star Julia Roberts and Clive Owen, according to Variety.com.
Roberts and Owen will play spies who try to manipulate both companies.
The film will mark the second collaboration between Wilkinson and directory Tony Gilroy. The two worked together for the film Michael Clayton, which has been nominated for 7 Oscars. We can next see Tom Wilkinson in the film Valkyrie with Tom Cruise.
Billy Bob Thornton, who was previously married to Angelina Jolie, can be seen in the upcoming film The Informers.