The group, lead by singer Bono, won Best Album (How to Dismantle an Atomic Bomb), Best Song (Sometimes You Can’t Make It On Your Own), Best Rock Album, Best Rock Song (City of Blinding Lights), and Best Performance by a Rock Group.
Singer Mariah Carey, John Legend, and Kanye West, each nominated in eight categories, each earned three awards. Bono told Carey, "You sing like an angel."
Kelly Clarkson earned two awards, including Best Pop Album.
The evening also brought the first public appearance of Sly Stone since 1993. Many artists presented a tribute to Sly and the Family Stone.