Actress Brooke Shields was the first guest to arrive in Rome on Wednesday. Shields has become close friends with Holmes, as the two women gave birth to their children on the same day in the same hospital.
The wedding, which will take place on Saturday at the Odeschalchi Castle in Bracciano, boasts a guest list that includes Jennifer Lopez and Marc Anthony, Jim Carrey and Jenny McCarthy, Will Smith and Jada Pinkett Smith, John Travolta and Kelly Preston, Steven Spielberg and his wife Kate Capshaw, and many others.
It was in Rome in May, 2005 when Cruise, 44, and Holmes, 27, were photographed together for the first time. Two months later, the actor proposed to Holmes at the base of the Eiffel Tower in Paris. Since then, the two have become parents to a daughter, Suri, who was born last April.